Equipoise abandoned? Randomization and clinical trials.
نویسندگان
چکیده
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منابع مشابه
A critique of clinical equipoise. Therapeutic misconception in the ethics of clinical trials.
A predominant ethical view holds that physician-investigators should conduct their research with therapeutic intent. And since a physician offering a therapy wouldn't prescribe second-rate treatments, the experimental intervention and the best proven therapy should appear equally effective. "Clinical equipoise" is necessary. But this perspective is flawed. The ethics of research and of therapy ...
متن کاملEquipoise and the ethics of randomization.
It is widely accepted that randomized controlled clinical trials yield the most reliable evidence about the effects of clinical carel. In this article we discuss the ethical importance of 'equipoise'-the condition which applies when there is no preference between the treatment options to be compared. We ask whether equipoise is an essential prerequisite for an ethical trial: are trials ethical ...
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OBJECTIVE The aim of the study was to investigate how doctors considered and experienced the concept of equipoise while recruiting patients to randomized controlled trials (RCTs). STUDY DESIGN AND SETTING In-depth interviews with 32 doctors in six publicly funded pragmatic RCTs explored their perceptions of equipoise as they undertook RCT recruitment. The RCTs varied in size, duration, type o...
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BACKGROUND Progress in clinical medicine relies on the willingness of patients to take part in experimental clinical trials, particularly randomized controlled trials (RCTs). Before agreeing to enroll in clinical trials, patients require guarantees that they will not knowingly be harmed and will have the best possible chances of receiving the most favorable treatments. This guarantee is provide...
متن کاملEquipoise in Clinical Trials
“Do you have equipoise?” The question was simple, yet loaded with challenges. We were being invited to participate in a prospective randomized controlled phase 3 trial testing whether acute endovascular stroke therapy can be beneficial for patients presenting beyond 6 hours from symptom onset (≤6 hours is the currently accepted therapeutic time window for mechanical thrombectomy) when using per...
متن کاملQuality of Randomization in Clinical Trials Published in Persian Journals of Medical Sciences Indexed in Scopus during 2013-2017
Background and Objectives: Randomization is one of the principles of correct clinical trial. The aim of this study was to determine the quality of randomization in the published articles of clinical trials in the Persian-language journals indexed in Scopus. ed in Scopus D Methods: In this cross-sectional study, all clinical trials published in Persian journals indexed in Scopus during 2013-2...
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عنوان ژورنال:
- Annals of oncology : official journal of the European Society for Medical Oncology
دوره 24 10 شماره
صفحات -
تاریخ انتشار 2013